The NKI recently published the results of 8 years of research on TIL Therapy in NEJM. Explanation of the therapy can be found here. The publication and a Quick take video can be found at NEJM.
The lifecycle of SARS-CoV-2
Knowing the lifecyle of SARS-CoV-2 is crucial for making drugs against the virus. Maastricht University made this wonderful animation.
Revolutionary RNA drugs (in Dutch)
For most medications, as soon as you take the pill, the active substance spreads crisscrossing your entire body. Usually that's not a problem. But if it causes side effects in some places, it is less pleasant. RNA drugs are the solution. Roy van der Meel (Eindhoven University of Technology) explains in this lecture how this works.
Quest for antibodies - Hecklab
At the interface of art and science - athletic dancing bodies represent the equally flexible antibodies present in our body! Inspired by the research of the Hecklab of Utrecht University, the researchers worked together with video performers from Sensu and the dancers of the Aerialettes, to artistically imagine how we can best detect the best antibodies in our own bodies. to prevent diseases.
This video was made possible with financial support from the Utrecht Molecular Immunology Hub, the Utrecht Institute for Pharmaceutical Sciences and the Hecklab of Utrecht University as well as from the European Union's Horizon 2020 research and innovation programme for the proteomics infrastructure EPIX-XS (823839)
Janssen Pharmaceutics produced a video explaining how drugs are discovered and developed.
The science behind the discovery process in pharmaceutical development. A research & development process, lasting 14 years on average, will tell us whether a substance can be used safely and efficiently as a medicine. It’s a journey full of science, compassion, precision and responsibility.
This Ted talk from Francis Collins, director of the NIH, gives a good overview.
Today we know the molecular cause of 4,000 diseases, but treatments are available for only 250 of them. So what's taking so long? Geneticist and physician Francis Collins explains why systematic drug discovery is imperative, even for rare and complex diseases, and offers a few solutions -- like teaching old drugs new tricks. TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more.
100 Years Medicines
The English physician James LeFanu came up with the following list of medicial breakthroughs that changed society in his book "The rise and fall of modern medicine".
In nine of these 10 breakthroughs, medicines were essential.. And even open-heart surgery is not possible without anesthesia drugs. So, without exaggeration it can be stated that medicines have changed society dramatically. But science has changed as well, according to this summary of Nobel prizes for drug research: